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Ian Maze, Ph.D.

Dr. Paul Maze

Ian Maze, Ph.D.

Assistant Professor of Neuroscience and Pharmacological Sciences, Ican School of Medicine at Mount Sinai

Ian Maze, Ph.D., Assistant Professor in the Departments of Neuroscience and Pharmacological Sciences at the Icahn School of Medicine at Mount Sinai in New York City, is a neurobiologist with extensive training in both the molecular biology and chromatin biochemistry of transcriptional regulation in the mammalian central nervous system (CNS).

Dr. Maze received his B.S. in Microbiology from The Ohio State University, his Ph.D. training in Neuroscience under the supervision of Dr. Eric J. Nestler at the University of Texas Southwestern Medical Center in Dallas and at the Mount Sinai School of Medicine, and performed his postdoctoral work with Dr. C. David Allis at The Rockefeller University, where he

extended his research focus to the emerging field of Mechanistic Neuroepigenetics. Dr. Maze’s multidisciplinary research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult psychiatric disorders including major depressive disorder and substance use disorder.

Dr. Maze’s lab has recently discovered a highly novel role for monoamine neurotransmitters (e.g., serotonin, dopamine, etc.) in the brain, whereby these molecules can function independently from their roles in synaptic neurotransmission to directly impact gene expression patterns in the CNS. The Maze laboratory has also found that these fundamental mechanisms – e.g., histone serotonylation – are often perturbed in psychiatric disorders making them ideal candidates for both the diagnosis and potential treatment of these devastating illnesses.